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. 2020 Aug 4;12:6837–6847. doi: 10.2147/CMAR.S256624

Figure 2.

Figure 2

Taurine upregulated gene 1 (TUG1) knockdown inhibited the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cells. HeP3B and sk-Hep-1 cells were transfected with si-TUG-1, si-TUG-2 or si-NC. (A) qRT-PCR was used to detect the expression of TUG1. (B) 3-(4,5-Dimethyl-2-Thiazolyl)-2, 5-Diphenyl-2-H-Tetrazolium Bromide (MTT) assay was applied to measure cell proliferation at 0, 24, 48, 72 and 96 h in transfected HeP3B and sk-Hep-1 cells. (C) Wound-healing assay was conducted to evaluate the migration of transfected HeP3B and sk-Hep-1 cells. (D) Transwell invasion assay was used to detect the invasion of transfected HeP3B and sk-Hep-1 cells. **P < 0.01 vs the si-NC group. Scale bar = 100 μm, ×400 magnification. Data were represented as mean ± standard deviation (SD) of at least two independent experiments.