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. 2020 Aug 12;13:111. doi: 10.1186/s13045-020-00947-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Negative regulators of T cell immunity other than PD-1 and CTLA-4. Schematic illustrating receptors and their ligands regulating T cell immunity. Multiple immune checkpoint molecules are differentially implicated in the regulation of activated T cells including LAG-3, TIM-3, and TIGIT. Plus and minus signs denote stimulatory and inhibitory signaling respectively. Single-headed and double-headed arrows denote uni-directional and bi-directional signaling respectively. APC, antigen-presenting cell; TCR, T cell receptor; LAG-3, lymphocyte-activation gene 3; CD112R, CD112 receptor; MHC, major histocompatibility complex; FGL1, fibrinogen-like protein 1; DNAM-1, DNAX accessory molecule 1; TIGIT, T cell immunoreceptor with Ig and ITIM domains; TIM-3, T cell immunoglobulin mucin-3