Table 5.
Association between autoimmune thyroid disease and response to methotrexate at 3-month follow-up visit among 6025 RA -patients (3 395 non/moderate responders, 2 630 good responders) in the Swedish Rheumatology Quality Register (SRQ), imputed dataset
| AITD in non/moderate responders (n)*(cases) | AITD in good responders (n)* (controls) | OR (95% CI)† | OR (95% CI)‡ | |
|---|---|---|---|---|
| Overall | 376 (11) | 286 (11) | 0.95 (0.80–1.13) | 0.93 (0.78–1.10) |
| Sex | ||||
| Women | 336 (14) | 248 (15) | 0.93 (0.78–1.12) | 0.90 (0.75–1.08) |
| Men | 40 (4) | 38 (4) | 1.05 (0.66–1.69) | 1.03 (0.64–1.66) |
| Age group | ||||
| <45 years | 30 (9) | 17 (6) | 1.44 (0.76–2.76) | 1.43 (0.74–2.75) |
| ≥45 years | 346 (11) | 269 (11) | 0.92 (0.77–1.10) | 0.89 (0.75–1.07) |
| Serostatus | ||||
| RF and/or ACPA positive | 265 (11) | 192 (11) | 0.99 (0.81–1.22) | 0.95 (0.78–1.17) |
| RF and ACPA negative | 97 (10) | 81 (10) | 0.86 (0.62–1.20) | 0.85 (0.60–1.18) |
| Serostatatus unspecified | 14 (20) | 13 (16) | 1.19 (0.50–2.84) | 1.49 (0.59–3.72) |
*According to EULAR response criteria including imputed values on response status. Values are the numbers (%).
†Adjusted for age and sex.
‡Adjusted for age, sex, cortisone, HAQ, smoking. Multiple imputations=50.
AITD, autoimmune thyroid disease; HAQ, Health Assessment Questionnaire Disability Index; RA, rheumatoid arthritis.