Table 5.
Performance of different proteinuria cut-off values to predict long-term outcomes in individual studies
| Reference | Cut-off and timepoint | Sensitivity | Specificity | PPV | NPV | Outcome |
|---|---|---|---|---|---|---|
| Dall’Era, 2015 (ELNT)82 | 0.8 gr at 12 months | 81% | 78% | 88% | 67% | sCr ≤1 at 7 years |
| Tamirou, 2015 (MAINTAIN)83 | 0.7 gr at 12 months | 71% | 75% | 94% | 29% | sCr ≤1 at 7 years |
| Tamirou, 2016 (MAINTAIN)78 | 0.5 gr at 3/6/12 months | NR | NR | 89/90/92% | 21/29/32% | sCr ≤120% baseline at 10 years |
| Dall’Era, 2015 (ALMS)60 | 1 gr at 6 months | NR | NR | NR | NR | OR 0.3 for CR during maintenance |
| Ugolini-Lopes, 201784 | 0.8 gr at 12 months | 90% | 78% | 67% | 94% | sCr ≤1.5 at 7 years |
| Yang, 201521 | 1.2 gr (time-adjusted) | 92.1% | 83.9% | NR | NR | ESKD |
ALMS, Aspreva Lupus Management Study; CR, complete response; ELNT, Euro-Lupus Nephritis Trial; ESKD, end-stage kidney disease; NPV, negative predictive value; NR, not reported; PPV, positive predictive value; sCr, serum creatinine.