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. 2019 Oct 16;1(1):fcz025. doi: 10.1093/braincomms/fcz025

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© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rebound insomnia in patients treated with triazolam after abrupt drug withdrawal. The figure shows that after abrupt drug discontinuation the symptoms of insomnia (measured as total wake time) not only promptly return but there is a rebound of insomnia, that is worsening of the symptoms far above disease baseline from pre-treatment period (red arrow), in fact, this worsening is considerably greater than the maximal degree of improvement of sleep during the drug treatment. Adapted from Kales et al. (1983a).