Table 2.
Group comparison of MRI and OCT measures
| HC | AQP4-IgG+ NMOSD | Test statistics | |
|---|---|---|---|
| NBV [mL] (mean ± SD) | 1542.5 ± 79.4 | 1500.5 ± 88.5 | W = 441, P = 0.038 |
| Thalamus [mL] (mean ± SD) | 20.8 ± 1.76 | 20.5 ± 1.82 | W = 604, P = 0.858 |
| Caudate nucleus [mL] (mean ± SD) | 9.46 ± 1.12 | 8.96 ± 1.05 | W= 446, P = 0.0439 |
| Putamen [mL] (mean ± SD) | 13.0 ± 1.33 | 12.6 ± 1.53 | W = 498, P = 0.160 |
| Pallidum [mL] (mean ± SD) | 4.82 ± 0.35 | 4.57 ± 0.46 | W = 420, P = 0.020 |
| Hippocampus [mL] (mean ± SD) | 10.3 ± 1.18 | 10.3 ± 1.23 | W = 616, P = 0.969 |
| Amygdala [mL] (mean ± SD) | 3.66 ± 0.52 | 3.86 ± 0.58 | W = 745, P = 0.150 |
| Nucleus accumbens [mL] (mean ± SD) | 1.21 ± 0.22 | 1.11 ± 0.25 | W = 482, P = 0.111 |
| Brainstem [mL] (mean ± SD) | 29.7 ± 2.41 | 29.9 ± 2.51 | W = 653, P = 0.708 |
| Cortical thickness [mm2] (mean ± SD) | 2.68 ± 0.09 | 2.71 ± 0.15 | W = 703, P = 0.341 |
| T2 brain lesion count [n] [(median (range)] | 3 (0–62) | 13.5 (0–139) | W = 890, P = 2.84e−4 |
| T2 brain lesion volume [mL] (mean ± SD) | 0.33 ± 0.57 | 2.86 ± 7.13 | W = 975, P = 3.40e−6 |
| MUCCA [mm2] (mean ± SD) | 75.3 ± 7.67 | 69.2 ± 7.61 | W = 319, P = 3.70e−4 |
| pRNFL [μm] (mean ± SD) | 95.0 ± 9.70 | 82.6 ± 24.1 | W = 276, P = 0.130 |
| GCIP [mm3] (mean ± SD) | 1.90 ± 0.14 | 1.68 ± 0.33 | W = 201, P = 8.14e−3 |
| INL [mm3] (mean ± SD) | 0.94 ± 0.06 | 0.95 ± 0.08 | W = 343, P = 0.908 |
Group comparisons of imaging measures from MRI and OCT, without adjustments or multiple testing correction. Bolded test statistics indicate statistical significance.
AQP4-IgG+ NMOSD = aquaporin-4-immunoglobulin-G seropositive neuromyelitis optica spectrum disorders; GCIP = ganglion cell inner plexiform; HC = healthy controls; INL = inner nuclear layer; MUCCA = mean upper cervical cord area; NBV = normalized brain volume; pRNFL = peripapillary retinal nerve fibre layer.