Table 5.

Multivariable linear models for changes in AQP4-IgG+ NMOSD MRI, OCT and clinical measures

	ON attacks	Myelitis attacks	Other attacks	Combined attacks	Total number of attacks	Disease Duration (DD)	Interactions	Age	F-statistic	Adjusted R2	Model P-value
NBV	NA	NA	NA	β = −0.40, P = 0.159	NA	β = 0.25, P = 0.247	Combined: DD β = 0.44, P = 0.216	β = −0.67, P = 1.7e−5	9.922	0.5352	4.5e−5
Caudate nucleus	NA	NA	NA	β = −0.55, P = 0.067	NA	β = −0.61, P = 0.011	Combined: DD β = 0.85, P = 0.028	β = −0.51, P = 8.0e−4	8.277	0.4843	1.7e−4
Pallidum	β = −0.15, P = 0.365	β = 0.03, P = 0.870	NA	NA	NA	NA	Myelitis: ON β = 0.35, P = 0.109	β = −0.38, P = 0.013	3.310	0.1956	0.0215
Nucleus accumbens	NA	NA	NA	β = −0.85, P = 0.021	NA	β = −0.43, P = 0.124	Combined: DD β = 0.95, P = 0.042	β = −0.26, P = 0.118	3.579	0.2497	0.0182
Cortical thickness	NA	NA	NA		β = 0.18, P = 0.156	NA	NA	β = −0.61, P = 2.4e−5	13.88	0.4041	3.4e−5
MUCCA	NA	β = −4.1, P = 0.023	NA	β = 0.78, P = 0.511	β = −0.88, P = 0.348	β = 0.15, P = 0.907	Myelitis: Combined: Total β = 10.6, P = 0.366 Myelitis: Total: DD β = −14.1, P = 0.338	β = −0.12, P = 0.449	2.935	0.4479	0.0180
pRNFL	NA	NA	NA	NA	NA	β = −0.34, P = 0.107	NA	β = 0.17, P = 0.415	1.748	0.06365	0.1997
GCIP	NA	NA	NA	β = −0.35, P = 0.105	NA	NA	NA	β = 0.22, P = 0.294	2.055	0.08755	0.1542
EDSS	NA	NA	NA	NA	NA	β = 0.25, P = 0.121	NA	β = 0.50, P = 0.003	7.252	0.3013	0.0030

Multivariable linear regression models of associations between attack types and disease duration with MRI, OCT and EDSS score, with adjustment for age. Bolded test statistics indicate statistical significance.

DD = disease duration; EDSS = expanded disability status scale; GCIP = ganglion cell inner plexiform; MUCCA = mean upper cervical cord volume; NBV = normalized brain volume; ON = optic neuritis; pRNFL = peripapillary retinal nerve fibre layer; β = standardized coefficients in multivariable linear regressions.