Table 1.

Statistical details of clinical time course

Clinical outcome		Point estimate	SE	P
NIHSS	a	4.552	0.520	1.75e-13
	b	1.199	0.341	7.00e-04
	Δ	−3.033	0.320	6.03e-15
rGS	a	0.482	0.072	3.26e-09
	b	1.040	0.333	2.52e-03
	Δ	0.288	0.036	8.71e-12
FM	a	41.690	4.224	1.06e-15
	b	5.093	21.090	8.10e-01
	Δ	10.860	1.430	3.98e-11

Point estimates, standard errors and P-values for model parameters $a$ (initial value), $b$ (rate of change) and $\Delta$ (total amount of change) obtained from fitting the exponential model (1) to temporal profiles of clinical outcome parameters. Standard errors and P-values result from non-linear mixed-effects regressions fit using the R package nlme. P-values for $\Delta$ of less than 0.05 are marked in bold.

FM = Fugl-Meyer; NIHSS = National Institutes of Health Stroke Scale; rGS = relative grip strength; SE = standard error.