Table 3.

Statistical details of effect of lesion volume on global graph measures

		Joint model			Ipsilesional			Contralesional
		Estimate	SE	P	Estimate	SE	P	Estimate	SE	P
q50	a	0.473	0.005	6.62e-155	0.471	0.005	8.29e-80	0.473	0.006	1.20e-73
	b	1.054	0.736	0.1536	1.009	0.599	0.0962	1.018	3.004	0.7356
	Δ	−0.002	0.005	0.6575	0.007	0.005	0.1729	−0.002	0.006	0.7662
	Δipsi	0.012	0.005	0.0274
	Δvol	0.000	0.002	0.8546	−0.009	0.002	0.0002	−0.001	0.003	0.7092
	Δvol:ipsi	−0.011	0.003	4.90e-05
Efficiency	a	7.030	0.030	2.16e-231	7.008	0.031	1.14e-111	7.037	0.036	1.36e-106
	b	1.158	0.885	0.1921	1.089	0.787	0.1704	1.093	1.940	0.5749
	Δ	−0.025	0.030	0.4025	0.002	0.028	0.9546	−0.027	0.031	0.3831
	Δipsi	0.043	0.028	0.1304
	Δvol	0.009	0.014	0.5286	−0.033	0.013	0.0115	−0.003	0.014	0.8566
	Δvol:ipsi	−0.054	0.014	0.0002
Modularity	a	0.021	0.001	3.67e-34	0.021	0.001	1.27e-23	0.021	0.002	3.93e-20
	b	0.604	0.293	0.0403	0.996	0.455	0.0315	0.999	0.960	0.3014
	Δ	0.003	0.002	0.0760	0.002	0.001	0.2207	0.002	0.002	0.1785
	Δipsi	−0.002	0.002	0.2850
	Δvol	0.000	0.001	0.7787	0.002	0.001	0.0038	0.001	0.001	0.4957
	Δvol:ipsi	0.002	0.001	0.0058

Point estimates, standard errors and P-values of model parameters obtained from fitting the exponential model (1) to temporal profiles of global graph measures. In the joint model, total change Δ is modelled as a linear function of log lesion volume, with both intercept and slope allowed to vary between stroke und intact hemispheres. Standard errors and P-values result from non-linear mixed-effects regressions fit either jointly (‘joint model’) or separately for stroke (‘ipsilesional’) and intact (‘contralesional’) hemispheres, using the R package nlme. P-values of ${\Delta }_{\text{vol}}$ (separate) and ${\Delta }_{\text{vol}: \text{ipsi}}$ (joint) of less than 0.05 are marked in bold.

q₅₀ = median connectivity; SE = standard error.