. 2020 Jan 10;2(1):fcaa001. doi: 10.1093/braincomms/fcaa001

Table 4.

Statistical details (corrected for lesion volume) of association between change in global network topology and clinical outcome

		Pooled model			1 month			3 months			12 months
		Estimate	SE	P	Estimate	SE	P	Estimate	SE	P	Estimate	SE	P
NIHSS	q₅₀	−21.681	10.113	0.0354	−4.808	12.142	0.6956	−20.699	13.938	0.1517	−13.199	12.755	0.3120
	Efficiency	−5.140	1.944	0.0100	−1.254	2.359	0.5998	−4.160	2.492	0.1092	−2.597	2.172	0.2446
	Modularity	178.002	60.607	0.0044	11.984	61.468	0.8471	157.379	58.341	0.0132	44.011	52.645	0.4121
rGS	q₅₀	6.236	2.654	0.0218	3.535	3.433	0.3139	3.172	4.091	0.4472	3.240	2.823	0.2654
	Efficiency	1.179	0.587	0.0485	1.065	0.727	0.1567	0.454	0.785	0.5691	0.436	0.516	0.4094
	Modularity	−29.932	20.989	0.1585	1.017	20.549	0.9610	−9.405	24.304	0.7028	−12.808	14.035	0.3729
FM^a	q₅₀	−36.726	13.215	0.0069	−17.404	15.792	0.2814	−19.105	18.981	0.3251	−26.294	16.528	0.1259
	Efficiency	−5.192	2.610	0.0504	−2.291	2.722	0.4083	−2.622	3.609	0.4751	−3.089	2.841	0.2886
	Modularity	180.020	81.492	0.0303	−4.026	70.267	0.9548	105.828	90.111	0.2528	91.112	60.574	0.1468

Regression coefficients (point estimates, standard errors and P-values) on the link scale between change in global network measures and clinical outcome. Log-transformed lesion volume is included as a nuisance regressor. In the case of NIHSS and FM^a:=66-FM scores, quasi-Poisson regressions with a log-link are used; in the case of relative grip strength, a Gaussian regression with identity link is used. The first three columns (‘pooled model’) represent pooled estimates from joint two-stage regressions across the subacute and chronic stages. P-values 0.05 are marked in bold.

FM = Fugl-Meyer; NIHSS = National Institutes of Health Stroke Scale; rGS = relative grips strength; SE = standard error.