Figure 1.

[¹¹C]PBR28 GM uptake in eight twin pairs discordant for EM performance and concordant for TSPO genotype. (A) [¹¹C]PBR28 GM SUVs of twins with poorer EM performance (referred as cases) compared with their co-twins stratified into HABs and MABs. EM discordant twin pairs where case has at least aMCI based on two delayed free recall measures are shown with full lines. The GM composite SUV is the volume-weighted average of six ROIs including the prefrontal, parietal, lateral temporal, precuneus, posterior cingulate and mesial temporal cortex. (B) Statistically significant pairwise differences of [¹¹C]PBR28 SUVs in eight discordant twin pairs at the voxel level (the 0.05 family-wise error-corrected widespread bilateral critical cluster size was 119 790). The colour bar represents T-values, in which brighter colour indicates greater T-values (T = 2.998 corresponds to cluster defining threshold of P < 0.01). HABs, high-affinity binders; MABs, mixed-affinity binders; ROIs, region of interests.