Table 1.
Demographics
| Participant demographics summary | CN | MCI | Alzheimer’s disease | Total |
|---|---|---|---|---|
| Number of participants, N | 111 | 7 | 15 | 133 |
| Male gender, N (%) | 63 (65.8) | 4 (57.1) | 5 (33.3) | 72 (54.1) |
| Age (years), mean (SD) | 71.8 (6.3) | 75.6 (7.9) | 74.9 (9.1) | 72.3 (6.8) |
| Years of education, mean (SD) | 13.4 (2.7) | 11.9 (2.8) | 12.5 (3.0) | 13.2 (2.8) |
| APOE ε4 carriers, N (%) | 30 (27.0) | 3 (42.9) | 9 (60.0) | 42 (31.6) |
| Years of follow-up, mean (SD) | 4.1 (0.8) | 2.1 (1.2) | 2.6 (1.4) | 3.9 (1.1) |
| Number of data collections, median (range) | 4 (2–4) | 2 (2–3) | 2 (2–4) | 4 (2–4) |
| Centiloid scores at baseline, mean (SD) | 17.9 (31.0) | 62.6 (55.8) | 87.3 (39.5) | 28.2 (40.8) |
| TP42/40 at baseline, mean (SD) | 0.10 (0.05) | 0.09 (0.03) | 0.10 (0.10) | 0.10 (0.06) |
| Rate of change in TP42/40 per year, mean (SD) | 0.007 (0.01) | 0.003 (0.01) | 0.008 (0.01) | −0.01 (0.01) |
Bold fonts indicate statistically significant differences from the cognitively normal subgroup.
APOE = apoliporotein E; TP42/40 = total protein amyloid-β 42/40 plasma ratios.