Table 3.
Transmission of FFI or sFI to multiple knock-in mice lines
| Inoculum a | Knock-in mice line | Attack rate (n/n0) | Mean incubation period (days ± SEM) |
|---|---|---|---|
| FFI-Mother | Ki-Hu129M/M | 0/6 | ∼1037 |
| Ki-Hu129V/V | 0/5 | ∼998 | |
| Ki-ChM | 0/5 | ∼907 | |
| Ki-Bank | 6/7 | 454 ± 104 | |
| FFI-Child | Ki-Hu129M/M | 0/6 | ∼886 |
| Ki-Hu129V/V | 0/6 | ∼767 | |
| Ki-ChM | 5/6 | 502 ± 133 | |
| Ki-Bank | 0/5 | ∼903 | |
| sFI-H91 | Ki-Hu129M/M | 0/3 | ∼806 |
| Ki-Hu129V/V | 0/6 | ∼799 | |
| Ki-ChM | 4/5 | 342 ± 25 | |
| Ki-Bank | 0/6 | ∼803 | |
| sFI-I110 | Ki-Hu129M/M | 0/4 | ∼752 |
| Ki-Hu129V/V | 0/4 | ∼722 | |
| Ki-ChM | 3/6 | 394 ± 23 | |
| Ki-Bank | 0/5 | ∼770 | |
| sFI-T00/06 | Ki-Hu129M/M | 0/6 | ∼907 |
| Ki-Hu129V/V | 0/4 | ∼661 | |
| Ki-ChM | 5/6 | 572 ± 135 | |
| Ki-Bank | 2/7 | 690, 707 |
n: number of positive mice; n0: number of inoculated mice.
a
Intracerebral inoculation with 20 μl of a 10% (w/v) brain homogenate from either of the patients with FFI or sFI.