Table 4.
Previous reports of the experimental transmission of FFI and sFI using a mouse model
| Inocula | Number of patients (successful transmission) | Recipient | Reference |
|---|---|---|---|
| FFI | 1 | Wild-type NZW mice | Tateishi et al. (1995) |
| FFI | 2 | Tg (human PrP129M) mice | Collinge et al. (1995) |
| FFI | 3a | Tg (human/mouse PrP chimera)b mice | Telling et al. (1996) |
| sFI | 1 | Tg (human/mouse PrP chimera)b mice | Mastrianni et al. (1999) |
| FFI | 1c | Wild-type NZW mice Tg (hamster PrP) mice | Sasaki et al. (2005) |
| sFI | 1d | Ki (human PrP129MM) mice | Moda et al. (2012) |
a
Three of the four patients with FFI were transmitted to Tg mice. The inoculated Tg mice with one patient with FFI with SC and OD did not develop the disease after 350 days post-inoculation.
b
The Tg mice have the same PrP sequence of Ki-ChM mice.
c
This case has widespread SC and OD.
d
This case has widespread SC; however, OD has not been described.