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. 2020 Mar 17;2(2):fcaa029. doi: 10.1093/braincomms/fcaa029

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Expression of reactive A1 astrocyte markers in sCJD and control frontal cortex brain tissues and stratification to codon 129 genotype in sCJD. Symbols represent the following: ■, control; ●, sCJD brain tissues. (A) C3_log was significantly elevated in sCJD brain tissues compared with control samples (Student’s t-test, n = 8,35, P = 0.0029) and (B) in the sCJD tissues C3_log expression stratified according to codon 129 genotype (one-way ANOVA with a multiple comparisons test for linear trend, n = 18,11,6, P = 0.027). (C) GBP2_log was significantly elevated in sCJD brain tissues compared with control samples (Student’s t-test, n = 8,35, P = 0.0002). (D) Stratifying GBP2_log expression to codon 129 genotype was not statistically significant (one-way ANOVA with a multiple comparisons test for linear trend, n = 18,11,6).