Table 2.

Statistical results for the three-way ANOVAs for mRNA expression from Study #1

Brain region	Gene	Effect of sex, F (P)	Effect of TBI, F (P)	Effect of THC, F (P)	Significant interactions, F (P)
PFC	Bdnf	0.01 (0.96)	0.37 (0.55)	2.69 (0.12)	Sex × THC—5.95 (0.03) Sex × TBI × THC—6.96 (0.02)
	Cnr1	0.01 (0.91)	0.29 (0.60)	0.18 (0.68)	TBI × THC—7.50 (0.02) Sex × TBI × THC—5.88 (0.03)
	Comt	3.65 (0.07)	4.46 (0.05)	11.06 (<0.01)	N/A
	GR	0.64 (0.44)	0.11 (0.75)	2.46 (0.14)	Sex × TBI × THC—7.17 (0.01)
	Iba-1	8.25 (0.01)	0.01 (0.94)	2.64 (0.12)	Sex × TBI × THC—10.26 (<0.01)
	Vegf-2R	0.13 (0.72)	2.60 (0.13)	16.31 (<0.01)	TBI × THC—5.77 (0.03)
HPC	Bdnf	1.79 (0.20)	0.00 (0.99)	2.05 (0.17)	Sex × TBI—4.95 (0.04)
	Cnr1	0.39 (0.54)	0.92 (0.35)	1.72 (0.21)	TBI × THC—12.05 (<0.01)
	Comt	0.44 (0.52)	0.13 (0.72)	0.01 (0.94)	N/A
	GR	1.42 (0.25)	0.04 (0.85)	1.35 (0.26)	TBI × THC—6.48 (0.02)
	Iba-1	5.72 (0.02)	0.13 (0.73)	0.00 (0.98)	N/A
	Vegf-2R	6.39 (0.02)	0.49 (0.49)	0.02 (0.89)	N/A
NAc	Bdnf	8.57 (0.01)	0.87 (0.37)	14.14 (<0.01)	Sex × TBI × THC—6.22 (0.02)
	Cnr1	14.32 (<0.01)	4.12 (0.06)	0.23 (0.64)	N/A
	Comt	2.51 (0.13)	0.10 (0.75)	1.12 (0.31)	TBI × THC—7.31 (0.01)
	GR	0.01 (0.95)	1.38 (0.26)	6.93 (0.02)	N/A
	Iba-1	0.69 (0.42)	0.01 (0.92)	0.24 (0.63)	N/A
	Vegf-2R	0.08 (0.78)	0.75 (0.40)	0.27 (0.61)	TBI × THC—6.15 (0.03)