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. 2019 Jul 2;1(1):fcz005. doi: 10.1093/braincomms/fcz005

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© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intrathecal injection of Mre11 and ATM inhibitors promote significant axon regeneration at 6 weeks after SCI. (A) GAP43⁺ (green) immunoreactivity was largely absent in DC + vehicle-treated groups (Blue = DAPI⁺ nuclei). However, in DC + mirin and DC+KU-60019-treated rats, enhanced GAP43⁺ immunoreactivity was present in the rostral segment of the spinal cord in beyond the lesion site (#) where a large cavity remained. (B) Quantification of the % of axons at different distances rostral to the lesion site showed significantly enhanced numbers of GAP43⁺ regenerating axons at all distances tested after treatment with DC + mirin and DC+KU-60019. (n = 10 nerves/condition). Scale bars in A = 200 µm. Comparisons in B by one-way ANOVA with Dunnet’s post hoc test (DC + vehicle versus DC+KU-60019).