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. 2020 Jul 14;12(14):14037–14049. doi: 10.18632/aging.103224

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Copyright © 2020 Dai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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CNN3 silencing inhibits cell migration and invasion in vitro. (A, B) Cell migration and invasion were evaluated by a transwell assay (A) and the Transwell-Matrigel assay (B). Images on the left are representations, and results on the right are the statistical results of cell migration or invasion, where *p<0.05. (C) Wound healing assay to evaluate cell migration. Images on the left are representations, and results on the right are the statistical results of wound closure percentage. The wound area was analyzed using the Image Pro-Plus 6.0 software. The percentage of wound closure was calculated using the ratio of wound area at 0 h and 24 h. (D) Expression of tumor metastasis-related proteins MMP9, VEGF, vimentin, and E-cadherin was detected by western blotting. *p <0.05, when LV-shCNN3 vs LV-NC.