Table 2.
Multivariable analyses of association between APOE, BP and post-ICH outcomes
| Risk factorsa | Post-ICH outcomes |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ICH recurrence |
Small vessel ischaemic stroke |
Incident dementia |
Incident depression |
Gait impairment |
||||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| APOE genotype | ||||||||||
| APOE ε2(≥ 1 copy) | 1.26 (0.56—2.83) | 0.58 | 1.06 (0.84–1.33) | 0.62 | 1.32 (0.79–2.20) | 0.29 | 0.89 (0.45–1.78) | 0.74 | 1.21 (0.80–1.83) | 0.37 |
| APOE ε4(≥ 1 copy) | 1.87 (1.20–2.92) | 0.006 | 1.19 (1.01–1.41) | 0.047 | 1.85 (1.21–1.84) | 0.005 | 1.70 (1.10–2.63) | 0.018 | 1.56 (1.12–2.18) | 0.01 |
| BP measures | ||||||||||
| SBP (10 mmHg increase) | 1.33 (1.06–1.66) | 0.012 | 1.25 (1.01–1.57) | 0.039 | 1.69 (1.14–2.50) | 0.009 | 1.23 (1.01–1.50) | 0.049 | 1.45 (1.14–1.85) | 0.003 |
| DBP (10 mmHg increase) | 1.09 (0.99–1.20) | 0.080 | 1.20 (0.87–1.65) | 0.26 | 0.96 (0.88–1.04) | 0.33 | 1.29 (0.59–2.83) | 0.53 | 1.03 (0.92–1.15) | 0.60 |
a
All models included the following covariates for adjustment: self-reported race/ethnicity, history of prior ICH (lobar and/or non-lobar), educational level, ICH location, antiplatelet agent use and warfarin use.
DBP = diastolic blood pressure; ICH = intracerebral haemorrhage; SBP = systolic blood pressure.