Table 3.

Hypertension severity and post-ICH outcomes, stratified by APOE ε4 genotype

Risk factorsa	Post-ICH outcomes
	ICH recurrence		Small vessel stroke		Incident dementia		Incident depression		Gait impairment
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
APOE ε4: 0 copies
Normal BP	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Elevated BP	1.68 (0.54–5.20)	0.19	1.39 (0.92–2.10)	0.12	1.23 (0.60–2.50)	0.57	1.36 (0.98–1.88)	0.07	1.12 (0.95–1.32)	0.20
Hypertension: Stage 1	2.21 (1.14–4.30)	0.020	1.88 (1.02–3.46)	0.044	2.14 (1.25–3.67)	0.006	1.54 (1.10–2.16)	0.013	1.81 (0.91–3.59)	0.10
Hypertension: Stage 2	3.54 (1.40–8.92)	0.004	2.19 (1.07–4.47)	0.033	2.58 (1.23–5.42)	0.013	2.39 (1.26–4.53)	0.009	2.35 (1.19–4.46)	0.015
APOE ε4: ≥1 copy
Normal BP	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Elevated BP	2.11 (1.23–3.63)	0.004	1.69 (1.08–2.64)	0.022	1.90 (1.22–2.95)	0.004	1.25 (0.88–1.78)	0.22	1.74 (1.21–1.50)	0.003
Hypertension: Stage 1	3.05 (1.14–6.46)	0.002	2.49 (1.25–4.95)	0.01	2.81 (1.27–6.20)	0.011	1.60 (1.15–2.23)	0.007	2.84 (1.20–6.71)	0.018
Hypertension: Stage 2	4.21 (1.53–11.59)	0.003	3.12 (1.41–6.92)	0.006	4.08 (1.58–10.41)	0.004	2.77 (1.23–6.21)	0.015	3.33 (1.34–8.25)	0.01

^aAll models included the following covariates for adjustment: self-reported race/ethnicity, history of prior ICH, educational level, ICH location, antiplatelet agent use and warfarin use.

ICH = intracerebral haemorrhage; BP = blood pressure.