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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Feb 11;140:1–9. doi: 10.1016/j.yjmcc.2020.02.004

Fig. 1.

Fig. 1.

Purinergic receptor classification and their activated intracellular components. Purinergic receptors are divided to P1 and P2 classes. P1 receptors consist of A1, A2A, A2B and A3 receptors. A1 and A3 receptors are negatively coupled to adenylyl cyclase (AC) through the Gi/o and activation of those receptors decreases cAMP levels, whereas A2A and A2B receptors are positively coupled to AC through Gs and enhance cAMP levels. The P2 receptors are further classified into two major families: ionotropic P2X and metabotropic P2Y receptors. Activation of P2X receptors increases sodium and calcium permeability, while activation of P2Y receptors either affects AC and alter cAMP levels or activates phospholipase C (PLC) and release intracellular calcium.