. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: J Mol Cell Cardiol. 2020 Feb 11;140:1–9. doi: 10.1016/j.yjmcc.2020.02.004

Table 5.

Purinergic receptor-mediated vascular function in the heart.

Organ	Species	Diabetic model	Nucleot(s)ide/stimuli	Purinergic receptor	Vascular effect	Reference
Heart	Swine	STZ and high-fat diet	Up₄A	A_2AR, P2X₇R, P2Y₁R	Coronary relaxation -	[70]
	Ossabaw miniature swine	Metabolic syndrome	ADO/the ADO analogue	A_2BR	CBF/coronary relaxation -	[65]
	Mouse	STZ	The A_2AR agonist	A_2AR	CBF/coronary relaxation↑	[64]

ADO: adenosine; CBF: coronary blood flow; STZ: streptozotocin; Up₄A: uridine adenosine tetraphosphate; ↑: increased effect; ↓: decreased effect; −: no effect vs. control group.