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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Feb 11;140:1–9. doi: 10.1016/j.yjmcc.2020.02.004

Table 7.

Purinergic receptor-mediated vascular trophic action.

Organ Species Diabetic model Nucleot(s)ide/stimuli Purinergic receptor Vascular effect Reference
HUVECs Human GDP A1R, A2BR ADO↑ [19,20]
High glucose ATP, UTP P2X4R, P2X7R Inflammatory genes↑; ROS↑; NO↓ [22,96]
Monocytes Human Type 2 diabetic patients P2X7R Plasma C-reactive protein↑ [99]
Aorta SMCs Mouse High glucose UTP P2Y2R, P2Y6R NFAT↑ [97]

ADO: adenosine; GDP: gestational diabetic pregnancy; HUVECs: human umbilical endothelial cells; NFAT: nuclear factor of activated T-cells; NO: nitric oxide; ROS: reactive oxygen species; ↑: increased effect; ↓: decreased effect.