. Author manuscript; available in PMC: 2020 Aug 13.

Published in final edited form as: J Neurosurg Spine. 2018 May 25;29(2):220–225. doi: 10.3171/2017.12.SPINE17920

TABLE 4.

Summary of previous series of SBRT for benign spinal lesions

Author & Year	No. of Patients	Dose (Gy)/No. of Fractions	Histology (no. of tumors)^*	Median Follow-Up (mos)	Previous Treatment	Local Control	Late Toxicity
Chang et al., 1998	3	21/3 (hemangioblastoma); 21/1 (AVM)	Hemangioblastoma (2); AVM (1)	18	None	33%–70% size reduction	None
Dodd et al., 2006	51	16/1–30/5	Schwannoma (30); meningioma (16); neurofibroma (9)	36	Surgery (51%)	Partial response at all sites	Grade 2+ radiation myelopathy (n = 1)
Ryu et al., 2001	11	11/1–25/5	Hemangioblastoma (1); AVM (6); schwannoma (2); meningioma (1); chordoma (1)	6	Surgery (n = 4); XRT (n = 2)	100%	None
De Salles et al., 2004	3	12/1	Neurofibroma (2); meningioma (1)	6	Surgery (n = 3); XRT (n = 1)	70%	0%
Marchetti et al., 2013	18	10/1–25/5	Schwannoma (9); meningioma (11); neurofibroma (1)	43	Surgery (n = 14); XRT (n = 1)	100%	0%
Gerszten et al., 2012⁹	45	12/1–24/1	Schwannoma (16); meningioma (10); neurofibroma (14)	32	Surgery (n = 21); XRT (n = 2)	NR	0%
Gerszten et al., 2012¹⁰	40	11/1–21/3	Schwannoma (15); meningioma (8); neurofibroma (7)	26	Surgery (n = 18); XRT (n = 4)	100%	0%
Gerszten et al., 2008	73	15/1–25/3	Schwannoma (35); meningioma (13); neurofibroma (25)	37	Surgery (n = 19); XRT (n = 6)	100%	Grade 2+ radiation myelopathy (n = 3)
Gagnon et al., 2009	13	21/3–37.5/5	Schwannoma (6); meningioma (5); neurofibroma (2)	12	63% surgery; XRT	NR	0%
Sahgal et al., 2007	16	10/1–30/5	Meningioma (2); chordoma (4); hemangioma (2); neurofibroma (11)	25	Surgery (n = 5); XRT (n = 2)	89%	0%
Current cohort	38	9/1–21/3	Schwannoma (13); meningioma (15); hemangioblastoma (7)	54	Surgery (n = 25); XRT (n = 8)	76%	Grade 2+ radiation myelopathy (n = 1)

AVM = arteriovenous malformation; NR = not reported; XRT = conventional radiotherapy.

Some patients had more than 1 tumor.