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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Sci Transl Med. 2020 Feb 19;12(531):eaay4006. doi: 10.1126/scitranslmed.aay4006

Fig. 4. Acute in vivo validation of primary biomimetic valve function in juvenile and adult sheep.

Fig. 4.

(A and B) Fabricated prototypes implanted at two polar expansion states (1X and 1.8X) in the native pulmonary valve position of juvenile (N = 4) and adult (N = 4) sheep. Representative plots showing right ventricular and pulmonary artery pressures for the (C) 1X and (D) 1.8X valve geometries. Corresponding pulmonary artery flow for the (E) 1X and (F) 1.8X valve geometries. Representative echocardiographic images of implanted valves, demonstrating change in coaptation length (Cl) between the (G) baseline (1X, 14 mm ID) and (H) fully expanded (1.8X, 25 mm ID) geometries. ID = internal diameter.