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. 2020 Jul 28;61(8):38. doi: 10.1167/iovs.61.8.38

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Figure 6. — (A) Confocal photomicrographs of terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL)-positive cells in the lens epithelium at P3 (red: apoptosis; blue: DAPI). (B) Number of TUNEL-positive cells in each group. Few TUNEL-positive cells can be seen in lenses from the control group. Massive TUNEL-positive cells were found in the lens epithelium of MNU-treated rats. The AI of the 50-mg/kg group was not significantly different from that of the control group. The AI of the 60- and 70-mg/kg groups was significantly higher than that of the control group. (C) Total superoxide dismutase (SOD) activity in the lenses of each animal group. Treatment with 70 mg/kg MNU caused a significant reduction in total SOD, compared to levels observed in the control group. (D) Mn-SOD activity in lens tissue from each. Treatment with 70 mg/kg MNU caused a significant reduction in Mn-SOD levels, compared to those observed in the control group. (E) The level of reduced glutathione (GSH) in lenses from each group. Treatment with 70 mg/kg MNU caused a significant reduction in GSH, compared to levels observed in the control group. (F) Levels of malondialdehyde (MDA), a marker of lipid peroxidation, in lenticular samples from each group. The MDA concentration was significantly higher in the 70-mg/kg group than in the control group (1-way ANOVA followed by Dunnett's multiple-comparisons test, ****P < 0.0001, *** P < 0.001, ** P < 0.01 for comparisons with control group; n = 3; all values represent mean ± SEM).