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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Nano Today. 2020 Jun 20;34:100898. doi: 10.1016/j.nantod.2020.100898

Fig. 6.

Fig. 6.

A. Characteristics of the mucus barrier coating epithelium and strategies used for promoting mucus penetration (a. Mucus-inert nanoparticle b. Mucolytic agents c. Mucoadhesive nanoparticle d. Targeting inflammation e. Charge-changing nanoparticle). B. Architecture of the mucus network and structure of the heavily glycosylated mucin monomer. C. Charge-based transport behavior of short length peptides of varying net charge and spatial distribution in mucin gel, i. Cationic peptide, ii. Anionic peptide, iii. Block peptide and iv. Alternate peptide. Adapted from ref [45]. Printed with permission from Elsevier.