Table 1.
Description of baseline demographic and clinical characteristics.
| Overall study population |
Non- metastatic1 |
Metastatic2 | ||
|---|---|---|---|---|
| n=212 | n=167 | n=45 | ||
| Patients deceased, n (%) | 33 (16%) | 18 (11%) | 25 (56%) | |
| Survival time, months mean ± SD* | 21.6 ± 5.94 | 22.8 ± 4.55 | 17.4 ± 8.24 | <0.001 |
| Age at surgery, mean ± SD | 63.3 ± 12.54 | 64.6 ± 11.85 | 58.7 ± 14.02 | 0.005 |
| Age at death, mean ± SD* | 64.2 ± 13.32 | 68.9 ± 10.07 | 61.3 ± 14.44 | 0.11 |
| Age at blood donation, mean ± SD | 62.9 ± 12.49 | 64.1 ± 11.82 | 58.3 ± 13.90 | 0.005 |
| Time between blood draw and death (months) mean ± SD* | 9.7 ± 6.83 | 8.8 ± 7.68 | 10.2 ±6.38 | 0.47 |
| Time between diagnosis and surgery (days), mean ± SD | 61 ± 169 | 41 ± 165 | 133 ± 164 | 0.0014 |
| Time between surgery and blood draw (days) mean ± SD | 1.9 ± 6.51 | 2.1 ± 7.31 | 1.1 ± 0.79 | 0.098 |
| Sex, n (%) | ||||
| Female | 66 (31%) | 53 (32%) | 13 (29%) | 0.71 |
| Male | 146 (69%) | 114 (68%) | 32 (71%) | |
| BMI (kg/m2), n (%) | 0.021 | |||
| Underweight, <18.5 | 6 (3%) | 2 (1%) | 4 (9%) | |
| Normoweight, 18.5-24.9 | 69 (36%) | 51 (34%) | 18 (42%) | |
| Overweight, 25-29.9 | 86 (44%) | 69 (46%) | 17 (40%) | |
| Obese, ≥30 | 33 (17%) | 29 (19%) | 4 (9%) | |
| BMI (kg/m2), mean ± SD | 26.2 ± 4.26 | 26.6 ± 4.15 | 24.8 ± 4.39 | 0.012 |
| Tumor Site, n (%) | ||||
| Colon | 118 (56%) | 95 (57%) | 23 (51%) | 0.49 |
| Rectum | 94 (44%) | 72 (43%) | 22 (49%) | |
| Adjuvant treatment, n (%)* | 0.01 | |||
| No | 122 (60%) | 103 (65%) | 19 (43%) | |
| Yes | 81 (40%) | 56 (35%) | 25 (57%) | |
| Missing | 9 | 8 | 1 | |
| Neo-adjuvant treatment, n (%) | ||||
| No | 138 (65%) | 117 (70%) | 21 (47%) | 0.004 |
| Yes | 74 (35%) | 50 (30%) | 24 (53%) | |
| Fat Area (cm2), mean ± SD | ||||
| VFA, L3/4 | 178.30 ± 104.50 | 192.5 ± 105.46 | 140.9 ± 93.18 | 0.007 |
| SFA, L3/4 | 201.80 ± 94.55 | 211.9 ± 91.37 | 176.8 ± 98.83 | 0.053 |
| TFA, L3/4 | 376.92 ± 162.44 | 401.47 ± 153.00 | 316.20 ± 171.08 | 0.006 |
| VFA, L4/5 | 152.20 ± 83.56 | 165.8 ± 84.49 | 116.5 ± 70.26 | 0.001 |
| SFA, L4/5 | 233.80 ± 96.22 | 246.7 ± 91.98 | 201.8 ± 100.19 | 0.015 |
| TFA, L4/5 | 383.78 ± 149.11 | 410.54 ± 139.30 | 317.56 ± 153.67 | 0.001 |
Abbreviations: SD=Standard Deviation; BMI=Body Mass Index, VFA=Visceral Fat Area, SAT=Subcutaneous Fat Area.
1
Non-metastatic: colorectal cancer stages I-III
2
Metastatic: colorectal cancer stage IV
*
only deceased patients