Table 4.
Linear regression of subcutaneous and total fat areas (at level L3/L4 and L4/L5) and metabolites in metastatic colorectal cancer patients (stage IV) adjusted for age, sex and analytical batch.*
| Fat area | |||||
|---|---|---|---|---|---|
| Level L3/L4 | Metabolite * | Cases |
Standardized ß-coefficient |
pValue | pFDR2 |
| SFA | PC ae C40:2 | 38 | −0.65 | 0.0003 | 0.017 |
| SFA | PC ae C40:6 | 38 | −0.66 | 0.0002 | 0.017 |
| SFA | PC ae C34:0 | 38 | −0.59 | 0.0005 | 0.020 |
| SFA | PC aa C42:0 | 38 | −0.62 | 0.0007 | 0.024 |
| SFA | PC aa C42:5 | 38 | −0.59 | 0.0017 | 0.037 |
| SFA | PC ae C42:2 | 38 | −0.58 | 0.0015 | 0.037 |
| SFA | PC ae C30:0 | 38 | −0.56 | 0.0025 | 0.041 |
| SFA | PC ae C36:1 | 38 | −0.54 | 0.0026 | 0.041 |
| SFA | PC aa C40:6 | 38 | −0.54 | 0.0043 | 0.045 |
| SFA | PC aa C42:1 | 38 | −0.52 | 0.0046 | 0.045 |
| SFA | PC aa C42:4 | 38 | −0.53 | 0.0039 | 0.045 |
| SFA | PC ae C42:3 | 38 | −0.53 | 0.0042 | 0.045 |
| SFA | PC ae C44:6 | 38 | −0.50 | 0.0039 | 0.045 |
| SFA | PC ae C34:1 | 38 | −0.50 | 0.0053 | 0.048 |
| SFA | PC aa C38:0 | 38 | −0.49 | 0.0059 | 0.049 |
| TFA | PC aa C42:0 | 38 | −0.68 | 0.0008 | 0.048 |
| TFA | PC ae C40:6 | 38 | −0.68 | 0.0005 | 0.048 |
| Level L4/L5 | |||||
| SFA | PC ae C40:2 | 38 | −0.65 | 0.0003 | 0.034 |
| SFA | PC aa C42:4 | 38 | −0.56 | 0.0021 | 0.046 |
| SFA | PC aa C42:5 | 38 | −0.59 | 0.0015 | 0.046 |
| SFA | PC ae C30:0 | 38 | −0.57 | 0.0021 | 0.046 |
| SFA | PC ae C34:0 | 38 | −0.57 | 0.0009 | 0.046 |
| SFA | PC ae C40:6 | 38 | −0.57 | 0.0016 | 0.046 |
| SFA | PC aa C42:0 | 38 | −0.56 | 0.0029 | 0.046 |
| SFA | PC ae C34:1 | 38 | −0.52 | 0.0036 | 0.046 |
| SFA | PC ae C36:1 | 38 | −0.54 | 0.0027 | 0.046 |
| SFA | PC ae C42:2 | 38 | −0.53 | 0.0036 | 0.046 |
| TFA | PC aa C42_0 | 38 | −0.61 | 0.0019 | 0.030 |
| TFA | PC aa C42_4 | 38 | −0.60 | 0.0018 | 0.030 |
| TFA | PC aa C42_5 | 38 | −0.62 | 0.0019 | 0.030 |
| TFA | PC ae C30_0 | 38 | −0.60 | 0.0023 | 0.030 |
| TFA | PC ae C34_0 | 38 | −0.60 | 0.0010 | 0.030 |
| TFA | PC ae C34_1 | 38 | −0.62 | 0.0008 | 0.030 |
| TFA | PC ae C36_1 | 38 | −0.58 | 0.0023 | 0.030 |
| TFA | PC ae C36_2 | 38 | −0.53 | 0.0041 | 0.044 |
| TFA | PC ae C40_2 | 38 | −0.69 | 0.0002 | 0.028 |
| TFA | PC ae C40_6 | 38 | −0.65 | 0.0006 | 0.030 |
| TFA | PC ae C42_2 | 38 | −0.54 | 0.0058 | 0.048 |
| TFA | PC ae C44_6 | 38 | −0.53 | 0.0042 | 0.044 |
| TFA | SM C26:1 | 38 | −0.61 | 0.0014 | 0.030 |
| TFA | C16 | 38 | 0.55 | 0.0061 | 0.048 |
| TFA | C18:1 | 38 | 0.54 | 0.0058 | 0.048 |
| TFA | C18:2 | 38 | 0.56 | 0.0060 | 0.048 |
Abbreviations: SFA=Subcutaneous Fat Area, TFA: Total Fat Area, FDR=false discovery rate.
*
Presented are metabolites that were significant after FDR-adjustment.