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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Br J Nutr. 2020 Feb 5;123(10):1187–1200. doi: 10.1017/S0007114520000422

Fig. 2.

Fig. 2.

Hierarchical clustering heat map, based on Spearman partial correlations of B vitamins and one-carbon metabolites with inflammation and angiogenesis biomarkers, adjusted for age group, patient sex, BMI category, cancer stage and site, physical activity, multivitamin intake and smoking status. Biomarkers involved in the same or similar pathways (such as pyridoxal (PL), pyridoxic acid (PA) and pyridoxal-5’-phosphate (PLP)) cluster together in the heat map. Blue indicates inverse correlations, for example, between PLP and C-reactive protein (CRP). Orange and red represent positive correlations, for example, between CRP and serum amyloid A (SAA). This heat map was created with BioVinci 1.1.5 (BioTuring Inc.). sICAM-1, soluble intercellular adhesion molecule 1; sVCAM-1, soluble vascular cell adhesion molecule 1; MCP-1, monocyte chemoattractant protein 1; TMP, thiamin monophosphate; Thi, thiamin; pABG, para-aminobenzoylglutamic acid; Ribo, riboflavin; apABG, acetyl-pABG; mTHF, 5-methyl-tetrahydrofolate; FA, folic acid; tHcy, total homocysteine; VEGF, vascular endothelial growth factor; Cob, cobalamin.