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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Br J Nutr. 2020 Feb 5;123(10):1187–1200. doi: 10.1017/S0007114520000422

Fig. 3.

Fig. 3.

Gaussian graphical model (GGM) of biomarker correlations, conditioned on the presence of all other biomarkers (conditional r ≥ |0·20|). Biomarkers are represented by nodes (circles), and conditional correlations are connected by edges (lines). Orange nodes represent inflammation, yellow nodes represent angiogenesis biomarkers and green nodes represent B vitamins and one-carbon metabolites. The line width represents the strength of conditional correlation. Red lines indicate positive correlations, and blue lines represent inverse correlations. Vascular endothelial growth factor A (VEGF-A) conditional r < 0·20. The GGM was created with Cytoscape 3.6.1 (Cytoscape Consortium). sICAM-1, soluble intercellular adhesion molecule 1; MCP-1, monocyte chemoattractant protein 1; sVCAM-1, soluble vascular cell adhesion molecule 1; PLP, pyridoxal-5’-phosphate; PA, pyridoxic acid; PL, pyridoxal; apABG, acetyl-para-aminobenzoylglutamic acid; mTHF, 5-methyl-tetrahydrofolate; pABG, para-aminobenzoylglutamic acid; FA, folic acid; tHcy, total homocysteine; Thi, thiamin; TMP, thiamin monophosphate; Ribo, riboflavin; Cob, cobalamin; CRP, C-reactive protein; SAA, serum amyloid A.