Table 2.
Biomarkers of inflammation, angiogenesis and one-carbon metabolism among 238 colorectal cancer patients enrolled in the ColoCare Study
(Mean values and standard deviations; median values and interquartile ranges (IQR))
| Biomarkers | Mean | sd | Median | IQR |
|---|---|---|---|---|
| Inflammation and angiogenesis | ||||
| CRP (mg/l) | 275 | 51–7 | 380 | 192 |
| SAA (mg/l) | 425 | 73–0 | 7–05 | 284 |
| IL-6 (pg/ml) | 446 | 202 | 079 | 130 |
| IL-8 (pg/ml) | 31 9 | 102 | 809 | 101 |
| MCP-1 (pg/ml) | 209 | 155 | 175 | 100 |
| sICAM-1 (mg/l) | 046 | 018 | 0–43 | 020 |
| sVCAM-1 (mg/l) | 064 | 030 | 059 | 027 |
| TNFα (pg/ml) | 123 | 089 | 116 | 069 |
| VEGF-A (pg/ml) | 841 | 541 | 749 | 559 |
| VEGF-D (pg/ml) | 836 | 304 | 799 | 314 |
| B vitamins and one-carbon metabolites | ||||
| mTHF (nmol/l) | 224 | 14–4 | 188 | 14–0 |
| Folic acid (nmol/l) | 022 | 210 | 000 | 000 |
| apABG (nmol/l) | 128 | 222 | 085 | 0–54 |
| pABG (nmol/l) | 116 | 126 | 079 | 096 |
| Cobalamin (pmol/l) | 358 | 266 | 315 | 183 |
| Thiamine (nmol/l) | 825 | 702 | 694 | 4–50 |
| TMP (nmol/l) | 291 | 195 | 247 | 228 |
| Riboflavin (nmol/l) | 243 | 236 | 180 | 139 |
| Total homocysteine (μmol/l) | 133 | 5–45 | 123 | 607 |
| PLP (nmol/l) | 352 | 34–4 | 265 | 237 |
| PL (nmol/l) | 208 | 766 | 10–4 | 902 |
| PA (nmol/l) | 358 | 922 | 21 8 | 158 |
CRP, C-reactive protein; SAA, serum amyloid A; MCP-1, monocyte chemoattractant protein 1; sICAM-1, soluble intercellular adhesion molecule 1; sVCAM-1, soluble vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor; mTHF, 5-methyl-tetrahydrofolate; apABG, acetyl-para-aminobenzoylglutamic acid; pABG, para-aminobenzoylglutamic acid; TMP, thiamin monophosphate; PLP, pyridoxal-5’-phosphate; PL, pyridoxal; PA, pyridoxic acid.