Table 3.
Associations between one-carbon metabolites and inflammation biomarkers among 238 colorectal cancer patients enrolled in the ColoCare Study*
(β-Coefficients and 95 % confidence intervals)
| Inflammation biomarkers | One-carbon metabolites |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PLP |
mTHF |
|||||||||||
| Simple† |
Full‡ |
Simple† |
Full‡ |
|||||||||
| β | 95% CI | P | β | 95% CI | P | β | 95% CI | P | β | 95% CI | P | |
| CRP | −098 | −1·33, −0·64 | <0·0001 | −0·86 | −1·24, −0·50 | <0·0001 | −0·58 | −1·00, −0·16 | 0·007 | −0·71 | −1·18, −0·23 | 0·004 |
| SAA | −0·63 | −0·96, −0·30 | 0·0002 | −0·56 | −0·94, −0·19 | 0·003 | −0·52 | −0·91, −0·12 | 0·01 | −0·68 | −1·13, −0·23 | 0·003 |
| IL-8 | −0·25 | −0·45, −0·04 | 0·02 | −026 | −0·48, −0·04 | 0·02 | −0·12 | −0·36, 0·13 | 0·34 | −0·16 | −0·43, 0·11 | 0·24 |
| IL-6 | −0·74 | −1·00, −0·48 | <0·0001 | −0·69 | −0·97, −0·40 | <0·0001 | −0·20 | −0·52, 0·13 | 0·24 | −0·24 | −0·60, 0·11 | 0·17 |
| TNFα | −0·18 | −0·32, −0·05 | 0·009 | −0·15 | −0·30, −0·003 | 0·045 | −0·23 | −0·39, −0·07 | 0·005 | −0·2 | −0·38, −0·03 | 0·02 |
| Inflammation biomarkers | One-carbon metabolites |
|||||||||||
| apABG |
pABG |
|||||||||||
| Simple† |
Full‡ |
Simple† |
Full‡ |
|||||||||
| β | 95% CI | P | β | 95% CI | P | β | 95% CI | P | β | 95% CI | P | |
| CRP | 0·10 | −0·44, 0·64 | 0·71 | 0·05 | −0·52, 0·63 | 0·90 | 0·29 | −0·08, 0·66 | 0·13 | 0·39 | −0·03, 0·80 | 0·07 |
| SAA | −0·14 | −0·65, 0·37 | 0·59 | −0·17 | −0·72, 0·38 | 0·54 | 0·14 | −0·20, 0·49 | 0·42 | 0·19 | −0·20, 0·58 | 0·34 |
| IL-8 | −0·02 | −0·33, 0·29 | 0·89 | −0·04 | −0·36, 0·28 | 0·82 | 0·67 | 0·46, 0·87 | <0·0001 | 0·58 | 0·36, 0·81 | <0·0001 |
| IL-6 | 0·86 | 0·46, 1·25 | <0·0001 | 0·93 | 0·53, 1·33 | <0·0001 | 0·18 | −0·10, 0·47 | 0·21 | 0·11 | −0·20, 0·41 | 0·49 |
| TNFα | −0·07 | −0·28, 0·13 | 0·48 | −0·09 | −0·31, 0·12 | 0·12 | 0·17 | 0·03, 0·32 | 0·02 | 0·12 | −0·04, 0·27 | 0·13 |
PLP, pyridoxal-5’-phosphate; mTHF, 5-methyl-tetrahydrofolate; CRP, C-reactive protein; SAA, serum amyloid A; apABG, acetyl-para-aminobenzoylglutamic acid; pABG, para-aminobenzoylglutamic acid.
Biomarker values were log2-transformed to meet the normality assumptions for linear regression models.
Simple model: multivariable linear regression model, adjusted for: age group (<60, 60 to <70 and ≥70 years) and patient sex.
Full model: multivariable linear regression model, adjusted for: age group, patient sex, BMI category, cancer stage and site, physical activity, multivitamin intake and smoking status.