Table 5.
Associations of active folate species (5-methyl-tetrahydrofolate) with inflammation biomarkers, stratified by BMI and cancer stage among 238 colorectal cancer patients enrolled in the ColoCare Study*
(β-Coefficients and 95 % confidence intervals)
| Inflammation biomarkers | WHO BMI category† |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Underweight/normal weight <25 kg/m2 (n 87) |
Overweight 25 to <30 kg/m2 (n 110) |
Obese 30+ kg/m2 (n 40) |
P for heterogeneity |
|||||||||
| β | 95 % CI | P | β | 95 % CI | P | β | 95 % CI | P | Under-/normal v. overweight | Under-/normal weight v. obese | Overall | |
| CRP | −0·81 | −1·65, 0·02 | 0·06 | −0·22 | −0·95, 0·5 | 0·50 | −0·96 | −2·64, 0·71 | 0·24 | 0·30 | 0·68 | 0·43 |
| SAA | −0·78 | −1·48, −0·08 | 0·03 | −0·26 | −0·99, 0·48 | 0·50 | −1·33 | −3·29, 0·64 | 0·17 | 0·25 | 0·62 | 0·35 |
| IL-8 | −0·32 | −0·7, 0·06 | 0·10 | −0·26 | −0·73, 0·2 | 0·27 | 0·47 | −0·3, 1·24 | 0·22 | 0·86 | 0·08 | 0·20 |
| IL-6 | −0·49 | −1·05, 0·08 | 0·09 | −0·13 | −0·75, 0·48 | 0·70 | 0·47 | −0·16, 1·11 | 0·14 | 0·34 | 0·11 | 0·26 |
| TNFα | −0·03 | −0·29, 0·24 | 0·84 | −0·48 | −0·73, −0·24 | 0·0002 | −0·04 | −0·57, 0·48 | 0·86 | 0·004 | 0·95 | 0·009 |
| Inflammation biomarkers | Cancer stage† |
|||||||||||
| Stage I (n 57) |
Stage II (n 96) |
Stage III (n 85) |
P for heterogeneity |
|||||||||
| β | 95% CI | P | β | 95% CI | P | β | 95% CI | P | I v. II | I v. III | Overall | |
| CRP | −1·41 | −2·2, −0·62 | 0·0009 | 0·002 | −0·68, 0·68 | 0·99 | −0·22 | −1·48, −1·04 | 0·73 | 0·01 | 0·03 | 0·02 |
| SAA | −1·31 | −2·1, −0·55 | 0·001 | −0·14 | −0·8, 0·5 | 0·67 | −0·42 | −1·64, 0·79 | 0·49 | 0·01 | 0·03 | 0·02 |
| IL-8 | −0·51 | −0·98, −0·03 | 0·04 | −0·002 | −0·41, 0·41 | 0·99 | −0·27 | −0·86, 0·33 | 0·37 | 0·28 | 0·30 | 0·48 |
| IL-6 | −0·76 | −1·45, −0·06 | 0·03 | −0·04 | −0·48, 0·40 | 0·90 | 0·07 | −0·77, 0·90 | 0·88 | 0·04 | 0·03 | 0·05 |
| TNFα | −0·3 | −0·65, 0·04 | 0·08 | −0·18 | −0·47, 0·10 | 0·20 | −0·06 | −0·40, 0·29 | 0·75 | 0·70 | 0·65 | 0·89 |
CRP, C-reactive protein; SAA, serum amyloid A.
*
Biomarker values were log2-transformed to meet the normality assumptions for linear regression models.
†
Multivariable regression analysis adjusted for: age group (<60, 60 to <70 and ≥70 years), sex, BMI category, cancer stage and site, physical activity, multivitamin intake and smoking status.