Skip to main content
. 2020 Aug 13;15(8):e0237451. doi: 10.1371/journal.pone.0237451

Fig 2. Effects on the occurrence of the conditioned response (CR).

Fig 2

(A) The frequency of the CR occurrence (CR%) in cued (circles) and non-cued (triangles) trials in vehicle-injected control (a) and VU0255035-treated (b) groups. After two days of adaptation sessions (sp1–2), 8 mice of each group underwent 7 days of conditioning for the acquisition of the conditional CRs (acq1–7), followed by three days of conditioning with an injection of an exchanged solution to test the effects on expression of the acquired CR (exp1–3). Empty and closed symbols denote the administration of the vehicle and VU0255035, respectively. (B, C) The differential CR% calculated by subtracting the CR% in non-cued trials from that in cued trials (B) and the overall CR% calculated from the total number of CRs during the session irrespective of the trial types (C) in vehicle-injected control (squares) and VU0255035-treated (diamonds) groups. Empty and closed symbols indicate the administration of the vehicle (marked as vehicle (+)) and VU0255035 (denoted as VU0255035 (+)), respectively. The vertical bars indicate the standard error of the mean.