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. 2020 Aug 13;15(8):e0236879. doi: 10.1371/journal.pone.0236879

Fig 5. Effects of SC extract on the expression of Bcl-2 family proteins in prostate tissues in TP-induced BPH rats.

Fig 5

To induce BPH, all rats were daily received TP injection (5 mg/kg, S.C.), except for the control group along with appropriate drugs (finasteride, saw palmetto, SC extract) orally for 4 weeks. Western blotting was performed to assay Bcl-2 and Bax, the Bcl-2 family proteins. (A) Western blot analysis of prostatic Bcl-2 and Bax. (B, C) Relative densitometry evolution of Bcl-2 and Bax, the western blot data. (D) Bcl-2/Bax ratio, which is used as a rheostat for determining cell susceptibility to apoptosis. Abbreviations: Control (PBS, P.O.), BPH (5 mg/kg TP, S.C. + PBS, P.O.), Fina (5 mg/kg TP, S.C. + finasteride 10 mg/kg, P.O.), Saw (5 mg/kg TP, S.C. + saw palmetto 100 mg/kg, P.O.), SC 50 (5 mg/kg TP, S.C. + SC extract 50 mg/kg, P.O.). Data are expressed as the means ± SD (n = 6). ### p < 0.001 versus control group; *** p < 0.001 versus BPH group.