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. 2020 Aug 3;16(8):e1008981. doi: 10.1371/journal.pgen.1008981

Fig 2. Evolutionary conservation of the TRIB3 promoter 33-bp VNTR area across mammalian species and the geographical distribution of the TRIB3 33-bp VNTR alleles in human populations.

Fig 2

(A) Nucleotide sequence alignment of the human TRIB3 promoter 33-bp VNTR repeat unit and flanking areas with the corresponding sequence in various mammalian genomes. Only one copy of the repeat is shown for modern human and Denisovan and Neanderthal hominins. Alignment was produced using Clustal Omega and Boxshade, with identical nucleotides shown in black and conserved purines in grey. The location of the C/EBP-ATF binding site is highlighted, overlapping a highly conserved sequence element. (B) A map showing the allele frequency distribution of the human TRIB3 promoter 33-bp VNTR repeat in various populations around the world. The results are based on data from the Human Genome Diversity Project (HGDP). (C) Multi-allelic fixation index (FST) for TRIB3 33-bp repeat copy number alleles in HGDP superpopulations.