Fig 6. TRIB3 SNPs highlighted by genetic association studies are linked to 33-bp repeat copy number as well as TRIB3 mRNA expression in phenotype-relevant tissues.

SNPs localizing near the TRIB3 33-bp repeat and associated (or suggestive) for human phenotypes based on GWAS, PheWAS or other genetic association studies are shown. Using RNA-Seq and whole genome sequencing data from GTEx v8, the association between the lead SNP genotype and TRIB3 RNA expression level or TRIB3 33-bp repeat copy number was calculated using linear regression for the SNP allele effect. The k-mer counting method was used to estimate the TRIB3 33-bp repeat copy number from genome sequencing reads.