Table 1. Recent genetic studies of lacunar stroke (LS) and cerebral small vessel disease (cSVD).

SNP (single nucleotide polymorphism), GWAS (genome wide association study), WES (whole exome sequencing), ICH (intracerebral hemorrhage), WMH (white matter hyperintensity).

Study Type	Related Gene	Biomarker Studied	SNP	Locus
Single Gene43	COL4A1	LS, ICH	rs515201	13q34
Single Gene44	COL4A2	LS, ICH	rs4771674	13q34
Single Gene42	COL3A1	LS	rs1800255	2q32.2
Single Gene44	HTRA1	LS, ICH	rs79043147	10q26.13
Single Gene45	ACE	LS	rs464994	17q23.3
Single Gene46	MTHFR	LS, WMH	rs1801133	1p36.22
Single Gene47	APOE	WMH	rs429358	19q13.32
GWAS51	ZCCH14	LS, WHM	rs12445022	16q24.2
GWAS52	TRIM65	WMH	rs3744028	17q25
GWAS52	TRIM47	WMH	rs1055129	17q25
GWAS52	PMF1	WMH	rs1052053	1q22
GWAS53	SH3PXD2A	WMH	rs12357919	10q24.33
GWAS53	HAAO	WMH	rs11679640	2p21
GWAS53	PMF1-BGLAP	WMH	rs2984613	1q22
GWAS53	EFEMP1	WMH	rs78857879	2p16.1
WES54	C1ORF156	Stroke	rs1048177	1q24.2
WES54	XYLB	Stroke	rs17118	3p21.3
WES55	CSN3	LS	N/A	4q13.3
WES55	HLA-DPB1	LS	N/A	6p21.32
WES56	SH3TC1	WMH	N/A	4p16.1