Appendix 1—figure 1. The drive load due to wtf segregating within populations.

(A) From Equation S.1, n is the number of drivers in the population and t is the strength of drive. Wild-type fitness is relative to a population without any drivers. (B) Meiotic mutant invasion criteria with extrinsic costs. All curves assume f = 0.1. Other parameters are listed in the plot. A mutant is expected to invade when the parameters for t and n fall above the line of interest. (C) Narrow parameter space allows for stable equilibrium. Solid line represents t_critical, below which the segregation mutant cannot invade. Dashed line represents t_fixation, above which the mutant fixes. In the space between the lines, the equilibrium ranges from zero (solid line) to one (dashed line). n = 5, s_m = 0.2, s_s = 0.1, h = 1.