TABLE 3.

RANO Brain Metastases⁶¹

	Complete	Partial	Progressive	Stable
	response	response	disease	disease
Target lesion size	Disappearance of all lesions	30% or more decrease in the sum longest diameter	20% or more increase in the sum longest diameter; at least one lesion increased by 5 mm	30% or more decrease from baseline but 20% in sum longest diameter from nadir
New lesions	None	None	Yes	None
Corticosteroid use	No use	Stable to decreased	N/A	Stable to decreased
Neurological symptoms	Stable or improved	Stable or improved	Worse	Stable or improved

Criteria to assess for intracranial response in brain metastases and with the use of immunotherapy. Reprinted from Lin et al⁶¹ with permission from Elsevier.