TABLE 4.

RANO Immunotherapy⁶⁶

	6 mo or less from	More than 6 mo from
	start of immunotherapy	start of immunotherapy
New lesions indicate progression	No	Yes
Treatment continuation allowed if scans show progression (and clinically stable)	Yes	No
Repeat scan required to confirm progression	Yes, at least 3 mo from initial one	No

Criteria to assess for intracranial response in brain metastases and with the use of immunotherapy. Reprinted from Okada et al,⁶⁶ Copyright (2015), with permission from Elsevier.