Table 1:
Baseline demographic and clincial characteristics of the PAOS patients
Variables | All PAOS (n=17) | PAOS− (n=12) | PAOS+ (n=5) | p-value |
---|---|---|---|---|
Sex [M] | 8 (47%) | 3 (25%) | 5 (100%) | 0.005* |
Handedness [R] | 16 (94%) | 12 (100%) | 4 (80%) | 0.11 |
Education, yrs. | 16 (13–18) | 16 (12.5–17.5) | 16 (12.5–19) | 0.55 |
Age at onset, yrs. | 70 (63–73) | 70 (62.5–73) | 65 (55–78) | 0.83 |
Age at DAT scan, yrs. | 73 (64–75) | 73 (63–75) | 69 (61–81) | 0.75 |
Disease duration, yrs. | 3 (1.5–5) | 3 (1–5) | 4 (1.5–7) | 0.53 |
UPDRS-I/52 | 7 (3.5–8) | 6 (4–8) | 7 (1.5–10.5) | 0.96 |
UPDRS-II/52 | 3 (2.5–7) | 3 (2.25–7.25) | 4 (2.5–8) | 0.67 |
UPDRS-III/132 | 11 (9–21.5) | 11.5 (10–22.75) | 11 (6.5–19.5) | 0.56 |
FBI/72 | 10 (7.5–19.5) | 9 (6.25–11.75) | 18 (10.5–26) | 0.10 |
Limb apraxia score/60 | 58 (52–59) | 58 (51.5–58) | 59 (53.5–59) | 0.33 |
TRAILS-A MOANS | 8 (6–11.75) | 8 (6–11.75) | 7.5 (4.5–12) | 0.85 |
ASRS-3 total | 19 (11–23.75) | 14 (10–24) | 23 (14–23.5) | 0.5 |
Aphasia | 12 (71%) | 8 (67%) | 4 (80%) | 0.58 |
AOS type (phonetic/prosodic)# | 7(41%)/4(24%) | 5(42%)/3(25%) | 2 (40%)/1(20%) | 0.96 |
MoCA/30 | 25 (19–26) | 24 (19–27) | 25 (18–28) | 0.91 |
WAB-AQ/100 | 96 (92.5–97.6) | 95 (92.5–97.5) | 97 (81–99) | 0.4 |
PSIS/5 | 1 (0–1) | 0.5 (0–1) | 1 (0.5–1.5) | 0.3 |
PSP-RS/100 | 12 (7–17) | 11 (7–18.5) | 12 (6–19.5) | 0.9 |
PSP-GM/20 | 1 (0–3) | 1 (0–2.75) | 0 (0–3.5) | 0.8 |
Statistically significant.
Remaining cases had mixed features of both prosodic and phonetic
Data for sex, handedness, aphasia, and AOS type summarized as numbers (percentages) and for all other variables summarized as median (interquartile ranges). [M] represents male sex.
PAOS− means PAOS patients with normal DAT scan, PAOS+ means PAOS patients with abnormal DAT scan.