Table 4.
Exercise and laboratory parameters before and after the treadmill test
| Control subject (n = 10) | PKU subjects (n = 12) | p | |
|---|---|---|---|
| Aerobic time (sec) | 556 (480.3–683.5) | 498 (285–664) | 0.883 |
| Anaerobic time (sec) | 177 (129.8–204.3) | 154 (140.8–271.8) | 0.247 |
| HR resting | 71.5 (65.2–73.2) | 67 (64.2–73.7) | 0.228 |
| Max HR (beats/min) | 197.5 (191.8–203.3) | 188.5 (185.5–199) | 0.037 |
| Systolic BP resting | 126 (112–134.5) | 120.5 (109.3–126) | 0.153 |
| Max systolic BP (mmHg) | 172 (165–191.8 | 168 (162–172) | 0.426 |
| ∆ Systolic BP (mmHg) | 46.5 (36.2–65.2) | 51 (46–57) | 0.657 |
| Diastolic Bp resting | 71.5 (66–83.5) | 72.5 (67.5–83.2) | 0.708 |
| Max diastolic BP (mmHg) | 89 (84.7–97.2) | 90 (73–100) | 0.974 |
| ∆ Diastolic BP (mmHg) | 17.5 (6–26.2) | 20 (6–35) | 0.703 |
| VO2max (ml/min) | 3970 (3758–4108) | 3080 (2813–3768) | 0.004 |
| Relative VO2max (ml/kg/min) | 48.5 (46.5–59) | 45 (36.3–52.8) | 0.174 |
| Cumulative workload (MET) | 13.8 (13.2–16.8) | 12.8 (10.4–15.1) | 0.185 |
| Cumulative workload (Watt) | 336.5 (316–380.8) | 253.5 (207–303) | 0.003 |
| Max RQ | 1.08 (1.0–1.1) | 1.1 (1.08–1.1) | 0.070 |
| Resting lactate (mM) | 1.4 (1.0–1.7) | 1.2 (0.9–1.7) | 0.285 |
| Max lactate (mM) | 10.9 (9.3–11.8) | 9.3 (6.9–10.8) | 0.140 |
| Restitution 5′ lactate (mM) | 11.3 (10.4–13.4) | 9.1 (8.0–11.9) | 0.093 |
| Phe resting (μmol/L) | 43.7 (37.2–57.9) | 542.3 (467.9–709.4) | <0.001 |
| ∆ Phe exercise (μmol/L) | 1.8 (− 3.3–7.0) | 26.7 (2.8–65.1) | 0.027 |
| ∆ Phe restitution (μmol/L) | − 7.9 (− 20.4–− 2.9) | − 2.5 (− 50.3–22.5) | 0.882 |
| Tyr resting (μmol/L) | 46.6 (39.2–54.8) | 37.6 (29.6–49.6) | 0.199 |
| ∆ Tyr exercise (μmol/L) | − 1.45 (− 2.8–0.8) | − 3.5 (− 5.2–2.0) | 0.899 |
| ∆ Tyr restitution (μmol/L) | − 4.5 (− 6.5–− 1.7) | − 1 (− 5.7–2.5) | 0.111 |
| NE baseline (pg/ml) | 300.5 (250–442.5) | 287.5 (190.8–404.5) | 0.614 |
| NE exercise (pg/ml) | 5008 (3482–11,689) | 3726 (2401–4760) | 0.140 |
| ∆ NE (pg/ml) | 4745 (3175–11,159) | 3448 (2151–4324) | 0.122 |
| E baseline (pg/ml) | 54.5 (44.5–80.7) | 66 (51.5–74) | 0.662 |
| E exercise (pg/ml) | 507 (280.5–1327) | 457 (317.8–1306) | 0.956 |
| ∆ E (pg/ml) | 428.5 (164–1170) | 386 (250.3–1238) | 0.771 |
Values are presented as median (25th and 75th percentiles)
Abbreviations: ∆ change from resting, HR heart rate, BP blood pressure, VO2max maximal oxygen consumption, RQ respiratory quotient, Phe phenylalanine, Tyr Tyrosine, NE norepinephrine, E epinephrine