Table 6.

Genetic associations tested between SLC6A14 variants and diseases

rs ID (alleles)	MAF	Variant localization	Association with	Number of patients/cohort characteristics	Ref
rs2312054 (A/T)	0.21	SLC6A14 intron	Food intake	344 children, age 7–8 years	[70]
rs12391221 (C/A)	0.30	SLC6A14 intron	Food intake	344 children, age 7–8 years	[70]
rs2071877 (C/T)	0.30	SLC6A14 intron	Obesity	1267 obese adults and 649 lean controls (French)	[71]
			Adiposity	344 children, age 7–8 years	[70]
rs2011162 (C/G)	0.45	SLC6A14 exon 14; 3′UTR	Obesity	Two independent cohorts: 117 obese and 182 controls (Finnish); 837 obese and 968 controls (Finnish and Swedish)	[72]
			Obesity	1267 obese adults and 649 lean controls (French)	[71]
			Reduced fat oxidation in women	722 obese subjects of white European origin (541 women, 181 men), age 20–25 years	[73]
			Male infertility	370 infertile men and 241 fertile controls (Macedonian and Slovenian)	[74]
rs2312054(A)/ rs2071877(C)/ rs2011162(G) haplotype			Male infertility	370 infertile men and 241 fertile controls (Macedonian and Slovenian)	[74]

Chromosomic position (forward strand); Alleles (Minor), Minor allele Frequency (MAF), data were collected from Ensembl, 1000 Genomes, European population