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. 2019 Dec 14;77(17):3441–3452. doi: 10.1007/s00018-019-03362-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Inhibition of SRSF2 reversed the dysfunction of TILs. a IFN-γ production by TILs was determined in TILs or TILs co-cultured with tumor cell lines using an ELISA assay in three independent experiments. The data are represented as the mean ± SD. b IFN-γ production by TILs was determined in TILs in which the expression of SRSF2 was inhibited by siSRSF2 or these TILs co-cultured with tumor cell lines using an ELISA assay in three independent experiments. The data are represented as the mean ± SD. c–i The frequency of IFN-γ + and CD8 + TILs was assessed by flow cytometry in TILs in which the expression of SRSF2 was inhibited by siSRSF2 or these TILs co-cultured with tumor cell lines isolated from Sample 3 (c), Sample 4 (d), Sample 7 (e), Sample 10 (f), Sample 11 (g), Sample 12 (h), and Sample 13 (i). *p < 0.01