This analysis provides a synthesis of the most recently published long-term survival evidence for IPF patients and an indirect comparison of other outcomes, including acute exacerbations, loss of lung function, safety and treatment discontinuation (for any reason).

The data were synthesised in an economic model that assumed a Belgian healthcare payer perspective.

Our results indicated that nintedanib and pirfenidone have similar health-related quality of life benefits. Nintedanib had a lower overall cost than pirfenidone, driven by a lower treatment cost and assumptions regarding the risk of acute exacerbations.