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. 2020 Aug 7;11:1744. doi: 10.3389/fimmu.2020.01744

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Copyright © 2020 Jennewein, Mabuka, Papia, Boudreau, Dong, Ackerman, Ndung'u and Alter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyfunctionality determines clinical course. (A) The bars show the polyfunctionality profiles for the 10 participants showing the number of functions each subject has overall, and for each antigen-specific response at each of four timepoints. (B) Correlation between the CD4 count and the number of functions that each participant had at each of four timepoints, with one dot per subject per timepoint. (C) Correlation between CD4 count at 12 months and the change in total polyfunctionality from month 1 to 12. (D–F) Correlation between CD4 count at 12 months and the change in antigen-specific functionality for gp120- (D), gp41- (E), and p24- (F) specific functions from month 1 to month 12. Correlations are Spearman correlations.