Table 1.
Baseline patient characteristics (continuous variables expressed as median (IQR)). *BMI = Body Mass Index; †PPI = Proton Pump Inhibitors; §GERD-HRQL = Gastro-Esophageal Reflux Disease Health Related Quality of Life; ‡LESP = Lower Esophageal Sphincter Pressure; ※DEA = Distal Esophageal Amplitude; δIEM = Ineffective esophageal motility.
| F.U. < 6 years (n = 211) | F.U. 6–12 years (n = 124) | |
|---|---|---|
| Age, years | 46 (20) | 44 (20.8) |
| Male, n (%) | 139 (65.8) | 83 (66.9) |
| BMI*, kg/m2 | 25.4 (5) | 23.9 (4.5) |
| Duration of symptoms, years | 8 (11.3) | 6 (7) |
| PPI† use, years | 7 (7) | 4 (6) |
| GERD-HRQL§ total score | 19.5 (10) | 21 (9.5) |
| Esophagitis, n (%) | ||
| None | 167 (79.1) | 103 (83.1) |
| Grade A | 22 (10.4) | 11 (8.9) |
| Grade B | 18 (8.5) | 9 (7.2) |
| Grade C | 2 (1.0) | 1 (0.8) |
| Grade D | 2 (1.0) | 0 (0.0) |
| Barrett’s esophagus, n (%) | 10 (4.7) | 4 (3.2) |
| Hiatal hernia length, n (%) | ||
| None | 57 (27.0) | 18 (14.5) |
| 1 cm | 24 (11.4) | 37 (29.8) |
| 2 cm | 70 (33.2) | 44 (35.6) |
| 3 cm | 35 (16.6) | 20 (16.1) |
| ≥ 4 cm | 25 (11.8) | 5 (4.0) |
| Basal LESP‡, mmHg | 14.2 (15.4) | 15.1 (12) |
| DEA※, mmHg | 66 (40) | 63.0 (34.2) |
| IEMδ, n (%) | 19 (9.0) | 1 (0.8) |
| DeMeester score | 24.8 (26.8) | 31.3 (24.6) |
| % total time pH < 4 | 6.4 (6.8) | 8 (6.6) |