Table 4.
Comparison of HLA-DRB1 and HLA-DQB1 allele frequencies, stratified by rs9272219 genotype, in NMO patients and controls.
| rs9272219 | HLA Allele | NMO (n = 31) | Controls (n = 97) | P | ||||
|---|---|---|---|---|---|---|---|---|
| AF | n | Δ′ | AF | n | Δ′ | |||
| C | DQB1*04:02 | 0.0323 | 2 | 1 | 0.0155 | 3 | 1 | NS |
| DRB1*04:04 | 0.0484 | 3 | 1 | 0.0619 | 12 | 0.8473 | NS | |
| DRB1*04:07 | 0.0484 | 3 | 1 | 0.1598 | 31 | 0.94 | 0.01528 | |
| DQB1*03:02 | 0.0968 | 6 | 1 | 0.2887 | 56 | 1 | 0.00107 | |
| DQB1*03:03 | 0.0161 | 1 | 1 | 0.0103 | 2 | 1 | NS | |
| DQB1*05:01 | 0.0323 | 2 | 1 | 0.0773 | 15 | 1 | NS | |
| DQB1*06:01 | 0.0161 | 1 | 1 | 0.0155 | 3 | 0.6337 | NS | |
| DQB1*06:02 | 0.0161 | 1 | 0.7338 | 0.0567 | 11 | 1 | NS | |
| DQB1*06:04 | 0.0161 | 1 | 1 | 0.0309 | 6 | 1 | NS | |
| DRB1*01:01 | 0.0161 | 1 | 1 | 0.0206 | 4 | 1 | NS | |
| DRB1*01:02 | 0.0161 | 1 | 1 | 0.0258 | 5 | 1 | NS | |
| DRB1*07:01 | 0.0161 | 1 | 1 | 0.0876 | 17 | 1 | 0.04056 | |
| DRB1*13:02 | 0.0161 | 1 | 1 | 0.0361 | 7 | 1 | NS | |
| DRB1*15:01 | 0.0161 | 1 | 0.7338 | 0.0567 | 11 | 1 | NS | |
| DRB1*15:02 | 0.0161 | 1 | 1 | 0.0206 | 4 | 1 | NS | |
| A | DQB1*04:02 | 0.2742 | 17 | 1 | 0.1392 | 27 | 1 | 0.01415 |
| DRB1*03:01 | 0.0806 | 5 | 1 | 0.0412 | 8 | 1 | NS | |
| DRB1*08:02 | 0.2903 | 18 | 1 | 0.1237 | 24 | 1 | 0.00279 | |
| DRB1*14:02 | 0.0161 | 1 | 1 | 0.0309 | 6 | 1 | NS | |
| DRB1*16:02 | 0.1613 | 10 | 1 | 0.0515 | 10 | 1 | 0.00831 | |
| DQB1*03:01 | 0.3065 | 19 | 0.911 | 0.1546 | 30 | 1 | 0.00851 | |
| DQB1*02:01 | 0.0806 | 5 | 0 | 0.0412 | 8 | 1 | NS | |
| DQB1*03:19 | 0.0484 | 3 | 1 | 0.0103 | 2 | 1 | NS | |
| DRB1*11:02 | 0.0323 | 2 | 1 | 0.0155 | 3 | 1 | NS | |
| DRB1*11:04 | 0.0161 | 1 | 1 | 0.0206 | 4 | 1 | NS | |
| DRB1*14:06 | 0.0968 | 6 | 0.7153 | 0.0206 | 4 | 1 | 0.01497 | |
AF, allele frequency. Only Alleles with a frequency ≥ 0.01 in both groups are presented.